Association of the modified Glasgow prognostic score and prognostic nutritional index with duration of oral anamorelin administration in patients with cancer cachexia: a retrospective cohort study (2024)

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Volume 54 Issue 11 November 2024
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Kazuma Fujita

Department of Pharmacy, Akita University Hospital

,

Akita

,

Japan

Corresponding author. Department of Pharmacy, Akita University Hospital, 1-1-1 Hondo, Akita 010-8543, Japan. Tel: +81-18-884-6309, Fax: +81-18-836-2628, E-mail: k.fujita@hos.akita-u.ac.jp

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,

Yumiko Akamine

Department of Pharmacy, Akita University Hospital

,

Akita

,

Japan

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,

Haruka Igarashi

Department of Pharmacy, Akita University Hospital

,

Akita

,

Japan

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Yayoi Fukushi

Department of Pharmacy, Akita University Hospital

,

Akita

,

Japan

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, ,

Koji Fukuda

Department of Clinical Oncology, Akita University

,

Akita

,

Japan

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,

Masafumi Kikuchi

Department of Pharmacy, Akita University Hospital

,

Akita

,

Japan

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Hiroyuki Shibata

Department of Clinical Oncology, Akita University

,

Akita

,

Japan

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Japanese Journal of Clinical Oncology, Volume 54, Issue 11, November 2024, Pages 1165–1170, https://doi.org/10.1093/jjco/hyae086

Published:

29 June 2024

Article history

Received:

18 April 2024

Editorial decision:

16 June 2024

Accepted:

17 June 2024

Published:

29 June 2024

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    Kazuma Fujita, Yumiko Akamine, Haruka Igarashi, Yayoi Fukushi, Katsuya Sasaki, Koji Fukuda, Masafumi Kikuchi, Hiroyuki Shibata, Association of the modified Glasgow prognostic score and prognostic nutritional index with duration of oral anamorelin administration in patients with cancer cachexia: a retrospective cohort study, Japanese Journal of Clinical Oncology, Volume 54, Issue 11, November 2024, Pages 1165–1170, https://doi.org/10.1093/jjco/hyae086

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Abstract

Background

The modified Glasgow Prognostic Score (mGPS) and Prognostic Nutritional Index (PNI) are indicators of nutritional status in cancer patients; however, the effects of baseline mGPS and PNI on the duration of administration of the ghrelin receptor agonist anamorelin, which is used to treat cachexia in patients with cancer, are unclear. This study aimed to clarify the association of mGPS and PNI with the duration of oral anamorelin administration for patients who did not have beneficial effects from anamorelin.

Methods

The attending physician determined the duration of oral anamorelin administration based on discontinuation due to cancer progression, poor efficacy, adverse events, or death.

Results

The 12-week continuation rate of oral anamorelin was 30.4%. Univariate analysis revealed that an Eastern Cooperative Oncology Group performance status (ECOG-PS) of ≥2 (P<.001), concurrent chemotherapy (P=.002), albumin level (P=.005), C-reactive protein level (P=.013), and a mGPS of 2 (P=.014) were statistically significant predictors of the 12-week continuation rate of oral anamorelin. In the multivariate analysis, a mGPS of 2 remained a significant risk factor, and the ECOG-PS and concurrent chemotherapy had no effect on the association between the mGPS and 12-week continuation rate of oral anamorelin.

Conclusion

Patients with a mGPS of 2, compared with mGPS of 0 or 1, are less likely to maintain oral anamorelin therapy, regardless of the ECOG-PS or concurrent chemotherapy. Therefore, it is necessary to consider initiating anamorelin administration at mGPS 0 or 1.

modified Glasgow prognostic score, anamorelin, cancer cachexia, albumin, C-reactive protein

© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Topic:

  • cachexia
  • albumins
  • cancer
  • chemotherapy regimen
  • patient prognosis
  • prognostic nutritional index (pni)
  • eastern cooperative oncology group performance status scale

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